non random mutations

From: Bertvan@aol.com
Date: Sun Feb 20 2000 - 11:59:33 EST

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    I've often suspected (hoped) real scientists studying evolution could not
    possibly be as dogmatic as the usual materialistic Darwin-defender on the
    internet. Note the excerpt from the following article:

    ("That the rapid evolution is positively, not negatively driven is
    important," said Wu. "Positive selection indicates that the DNA changes
    are doing something better for the organism as opposed to something
    worse or nothing at all, which would be the case if the changes were
    just random mutations." )

    If some genes can mutate non-randomly, why not others? The mechanism for the
    "positive pressure" for sex genes to mutate (non randomly) is at present
    unknown. Until that mechanism IS known, I argue that anyone who wants to
    believe "God does it" is entitled. When all of nature is completely
    understood, I will gracefully acknowledge materialism. Until then,
    materialism should not be rammed down anyone's throats, including school
    children, as "scientific truth".

    Bertvan

    The article can be read at:

    http://www.uchospitals.edu/news/malegenes.html

    Genes pertaining to "maleness" evolve more rapidly than their non-sexual
    counterparts

    Researchers at the University of Chicago report in the January 20 issue
    of Nature that genes pertaining to male reproduction-those involved in
    sperm production, transfer and morphology-evolve much faster than their
    non-sexual counterparts.

    Chimpanzee
    Gorilla
    Researchers Chung-I Wu
    and Gerald Wyckoff

    Chung-I Wu, Ph.D., professor and chairman of the department of ecology &
    evolution at the University of Chicago, together with Gerald Wyckoff, a
    graduate student and Wen Wang, Ph.D., a postdoctoral fellow, argue that
    sexual pressure underlies this phenomenon.

    "The pressure on a male to find a mate and fertilize her eggs is
    constant, and the stakes of success or failure are enormous," said Wu.
    "Presumably, genes governing male reproduction are under continuous
    pressure to evolve ways to outcompete other males when it comes to
    fathering offspring."

    In previous research, Wu and colleagues found that genes related to
    sperm production in fruit flies, mice and rats evolved faster than other
    genes. In the January 20 Nature paper, Wu and his co-authors describe
    the accelerated evolution of male reproductive genes in man and other
    primates.

    "That the rapid evolution is positively, not negatively driven is
    important," said Wu. "Positive selection indicates that the DNA changes
    are doing something better for the organism as opposed to something
    worse or nothing at all, which would be the case if the changes were
    just random mutations."

    The title of the paper, "Rapid Evolution of Male Reproductive Genes in
    the Descent of Man," makes reference to Charles Darwin's book Descent of
    Man. "I chose this title because Darwin talks about how the drive to
    mate is perhaps the strongest driving force behind evolution," Wu
    explained. As Darwin wrote, the advantages of "conquering other males in
    battle or courtship, and thus leaving a numerous progeny are in the long
    run greater than those derived from rather more perfect adaptation to
    the conditions of life."

    Wu and colleagues examined a set of three homologous genes that may
    directly alter the morphology of sperm in humans, chimpanzees, gorillas
    and orangutans. When they compared the genes in different humans, they
    found that the genes were virtually identical, as would be expected in a
    comparison of genes from individuals of the same species.

    Next, the researchers compared the genes in humans and chimps and were
    surprised to find that they looked very different from one another. A
    well established theory in genetic evolution states that even after
    millions of years of evolution, homologous genes in closely related
    species, such as humans and chimps, are barely distinguishable from one
    another. That the human and chimp sperm genes were so radically
    different suggests exceedingly rapid evolution.

    "The genes in humans and chimps are evolving at the same rapid rate,"
    added Wu. When he compared the genes in humans and gorillas, which are
    more distantly related, he noticed that the rate of evolution of
    maleness genes was still accelerated, but at a much slower rate in
    gorillas.

    The researchers also surveyed 50 genes from humans and old world
    monkeys, of which 18 pertained to male reproduction and the rest did
    not. They found that 11 of the 18 male genes evolved much faster than
    the average rate of evolution of the non-sexual genes.

    Wu thinks that the rapid rate of evolution of male genes is indicative
    of the sexual behavior of the species. Chimps exhibit very promiscuous
    behavior. A female may mate with numerous males during her receptive
    phase. The competition to attract a mate, as well as internal sperm
    competition, puts intense pressure on chimp male genes to evolve
    rapidly.

    Conversely, gorillas employ a harem system where one high-ranking male
    has access to several females who mate only with him. In this case, the
    male can be relatively sure that he is the genetic father of any
    offspring produced by his harem. This takes some of the pressure off
    sperm-producing genes to mutate rapidly because they don't compete
    directly with other sperm in the female, said Wu.



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