Hox genes as phylogenetic markers

From: Lawrence Johnston (johnston@uidaho.edu)
Date: Fri Jun 02 2000 - 11:52:18 EDT

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    Dear ASA-o-philes -

    I was struck by a passage in the recent clipping that Glenn just sent us from
    _Evolution and Development_:

    Rudimentary understanding of molecular biology was sufficient to spot
    egregious errors, candidly dispatched by Eric Davidson. Well's claim that
    aspects of *Hox* gene control, instead of providing yet more evidence for
    homology and common ancestry, actually suggest that all metazoan phyla
    arose independently gives the flavor of what was offered.

    I'm no expert on Melecular Biology, but my mentor in that field tells me that
    horizontal gene transfer has made Hox genes, and perhaps other genes, unreliable
    indicators of phylogenetic affinities. She cites a classic example in which the
    fruit fly, Drosophila, was found to have the "Eye" gene which controlled development
    of eyes in flies. The same gene was found to control eye development in the mouse.
    But an even greater surprise came to find that C. Eleganz, the nematode workhorse
    animal of Biologists, also had the Eye gene, even though that animal has no eyes.

            She said this strange development had to be explained by interspecies gene
    transfer, which has been observed in the laboratory. This phenomenon seems to have
    dimmed the bright hope that molecular affinities would enable certitude for
    determining relatedness in construction of phylogenetic trees.

            Perhaps there are others on the List who are Biologists and know more about this
    development. It's fun to learn!
                                                    Larry

    "He has made everything beautiful in its time. He has also set
     eternity in the hearts of men" - - Ecclesiastes 3:11, NIV trans

    ================================================
    Lawrence H. Johnston 917 E. 8th st.
    professor of physics, emeritus Moscow, Id 83843
    University of Idaho (208) 882-2765
    http://www.uidaho.edu/~johnston/ =====================



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